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BIBTEX RIS

In vitro antiplasmodial activity of some plants used in Kisii, Kenya against malaria and their chloroquine potentiation effects

2003; Elsevier BV; Volume: 84; Issue: 2-3 Linguagem: Inglês

10.1016/s0378-8741(02)00327-6

ISSN

1872-7573

Autores

Francis W. Muregi, S.C. Chhabra, E.N.M. Njagi, Caroline Langat‐Thoruwa, Wilson Njue, Alloys S. S. Orago, Sabah A. Omar, I.O. Ndiege,

Tópico(s)

Drug-Induced Hepatotoxicity and Protection

Resumo

Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC50<100 μg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC50 values ranging less than 30 μg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC50 values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ.

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