Neither vitamin E nor donepezil delays progression from amnestic mild cognitive impairment to Alzheimer's disease in the long term
2006; BMJ; Volume: 9; Issue: 1 Linguagem: Inglês
10.1136/ebmh.9.1.20
ISSN1468-960X
Autores Tópico(s)Vitamin C and Antioxidants Research
ResumoPetersen RC, Thomas RG, Grundman M, et al . Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005;352:2379–88.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q Do vitamin E or donepezil delay the clinical diagnosis of Alzheimer’s disease in people with the amnestic form of mild cognitive impairment? ### ![Graphic][5] Design: Randomised controlled trial. ### ![Graphic][6] Allocation: Unclear. ### ![Graphic][7] Blinding: Double blind. ### ![Graphic][8] Follow up period: Three years. ### ![Graphic][9] Setting: Sixty nine sites in the United States and Canada; March 1999 to January 2004. ### ![Graphic][10] Patients: 790 people aged 55–90 years, with amnestic mild cognitive impairment of a degenerative nature. Other inclusion criteria: Clinical Dementia Rating of 0.5; Mini-Mental State Examination score 24 to 30; impaired memory; and Logical Memory delayed recall score about 1.5 to 2 standard deviations below education adjusted norm. ### ![Graphic][11] Intervention: Donepezil (10 mg daily) plus placebo vitamin E; vitamin E (2000 IU daily) plus placebo … [1]: {openurl}?query=rft.jtitle%253DN%2BEngl%2BJ%2BMed%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa050151%26rft_id%253Dinfo%253Apmid%252F15829527%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa050151&link_type=DOI [3]: /lookup/external-ref?access_num=15829527&link_type=MED&atom=%2Febmental%2F9%2F1%2F20.atom [4]: /lookup/external-ref?access_num=000229638900004&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif [11]: /embed/inline-graphic-7.gif
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