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New aspartame-like sweeteners containing L-(αMe)Phe

1992; Elsevier BV; Volume: 2; Issue: 5 Linguagem: Inglês

10.1016/s0960-894x(00)80168-7

1464-3405

Stefano Polinelli, Quirinus B. Broxterman, H. Schoemaker, Wilhelmus H. J. Boesten, Marco Crisma, G. Valle, Claudio Toniolo, J. Kamphuis,

Amino Acid Enzymes and Metabolism

The [L-(αMe) Phe]2-analogue of aspartame was synthesized and analyzed by X-ray diffraction. This compound is as sweet as aspartame itself but far more stable at pH=4. Several N-protected analogues were synthesized. The N-formylcarbamoyl [L-(αMe Phe)]2-aspartame analogue is also sweet. The compounds fit well within the sweet perception model as developed by Temussi, Toniolo and coworkers.