Forsythoside a inhibits the avian infectious bronchitis virus in cell culture
2010; Wiley; Volume: 25; Issue: 3 Linguagem: Inglês
10.1002/ptr.3260
ISSN1099-1573
AutoresHuawei Li, Jufu Wu, Zhongwen Zhang, Yuanyuan Ma, Fangfang Liao, Yu Zhang, WU Guo-juan,
Tópico(s)Phytochemistry and Biological Activities
ResumoForsythoside A is a polyphenolic constituent of the fruits of Forsythia suspensa Vahl. which is widely used as an antiinflammatory agent in traditional Chinese medicine. In the present study, the effects of forsythoside A on cell infection by avian infectious bronchitis virus were assessed. A real-time fluorescence quantitative PCR assay was used to determine mRNA content of IBV N gene. The pretreatment of cells with forsythoside A, adding forsythoside A post infection of cells, and treatment of virus with forsythoside A were analysed. The inhibitory effect of forsythoside A was confirmed by infecting primary chicken embryo kidney cells. Infected cells were inhibited by forsythoside A treatment. The data indicated that forsythoside A has the potential to prevent IBV infection in vitro. Copyright © 2010 John Wiley & Sons, Ltd.
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