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For-Met-ΔzLeu-Phe-OMe: A new active analog of chemotactic N-formyltripeptides with β-turn crystal conformation

1991; Elsevier BV; Volume: 32; Issue: 34 Linguagem: Inglês

10.1016/s0040-4039(00)92174-9

1873-3581

Giampiero Pagani Zecchini, Mario Paglialunga Paradisi, Ines Torrini, Gino Lucente, E. Gavuzzo, Fernando Mazza, G. Pochetti, Susanna Spisani,

Nitric Oxide and Endothelin Effects

Abstract The title Δ z Leu containing N-formyltripeptide 2 , has been synthesized and found active in the superoxide production whereas inactive in the stimulation of human neutrophil migration. The X-ray crystallographic analysis reveals that 2 adopts a β-turn conformation stabilized by an intramolecular H-bond.