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Effect of glibenclamide on sugar transport by fed, starved and diabetic rat small intestine

1973; Elsevier BV; Volume: 22; Issue: 9 Linguagem: Inglês

10.1016/0006-2952(73)90164-0

1873-2968

J. D. Teale, Andrew Love,

Drug Transport and Resistance Mechanisms

Glucose transfer by jejunum from starved rats is not as susceptible to gliben-clamide as is transfer by jejunum from fed or diabetic animals. Similarly, with fed rats, glucose transfer by ileum is not affected to the same extent by glibenclamide as is transfer by jejunum. Galactose transfer is less affected by glibenclamide than is glucose transfer, using jejunum from fed, starved or glucose-fed starved animals. Glibenclamide appears to deplete energy supplies in the intestinal cell by an uncoupling action. As a result, the transfer of a metabolized sugar, such as glucose, is markedly decreased because of an increase in metabolic rate. Consequently glucose transfer by intestinal tissue with a comparatively lower level of glycolysis is less affected. Similarly, the transfer of galactose is relatively unaffected compared with glucose transfer, since galactose is not involved in intracellular metabolism.