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Artigo Revisado por pares
BIBTEX RIS

Electrocardiogram Changes and Therapeutic Desipramine and 2-Hydroxy-Desipramine Concentrations in Elderly Depressives

1986; Cambridge University Press; Volume: 148; Issue: 6 Linguagem: Inglês

10.1192/bjp.148.6.676

ISSN

1472-1465

Autores

Stan Kutcher, Kieran F. Reid, James Dubbin, Kenneth I. Shulman,

Tópico(s)

Electroconvulsive Therapy Studies

Resumo

ECG parameters in elderly depressed in-patients were assessed during routine desipramine treatment. Significant changes (prolonged PR and PRS intervals and a decreased QTc interval) were found, related only to steady state concentrations of desipramine's major metabolite--2-hydroxy-desipramine. Potentially clinically significant changes developed in 40% of the patients. All serum drug concentrations were within therapeutic limits. Previous assurances about desipramines's cardiac safety in the elderly may need to be re-evaluated.

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