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The identification of 4,6-quinolinediol and 4,8-quinolinediol in the urine of hens

1967; Elsevier BV; Volume: 136; Issue: 1 Linguagem: Inglês

10.1016/0304-4165(67)90328-5

1872-8006

Ryo Kido, Tomoo Noguchi, Tsutomu Tsuji, Yuichi MATSUMURA,

Tryptophan and brain disorders

1. A study was carried out on the urinary excretion of quinoline derivatives derived from tryptophan in hens under normal and tryptophan-loading conditions. 2. The administration of tryptophan resulted in the occurence of 4,6-quinolinediol, 4,8-quinolinediol, 6-hydroxykynurenic acid, kynurenic acid, xanthurenic acid and some other unidentified compounds, although no quinoline derivative was detected in normal urine. 3. Hitherto 4,6-quinolinediol has not been shown to be a natural product in any species. This would, therefore, seem to be the first demonstration of the occurence of this quinoline derivative. 4. A compound identified as 4,8-quinolinediol was found in hens' urine. This would appear to be the first example of the excretion of a quinolinediol by an animal following the ingestion of a normal nutrient. 5. The possible routes of formation of 4,6-quinolinediol and 4,8-quinolinediol are discussed.