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BIBTEX RIS

Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação

2010; Brazilian Chemical Society; Volume: 33; Issue: 2 Linguagem: Inglês

10.1590/s0100-40422010000200041

ISSN

1678-7064

Autores

Jardes Figuerêdo do Rêgo, Jacira Izidório de Moura, Graziella Ciaramella Moita,

Tópico(s)

Pharmaceutical Practices and Patient Outcomes

Resumo

METHOD DEVELOPMENT AND VALIDATION.Spectrophotometric methods of zero order, first and second derived order had been developed for olanzapine determination in tablets using ethanol and isopropanol as solvent.The two solvents revealed to be adequate.For the three methods the calibration curve coefficient of correlation had been greater than 0.9998 with limit of detection varying from 0.068 to 0.190 mg L -1 , in ethanol, and 0.026 to 0.205 mg L -1 , in isopropanol.The inter-day precision was inferior to 1.1 and 1.9 mg L -1 for ethanol and isopropanol, respectively.The average recoveries varied from 98 to 101%, in ethanol and 99 to 103% in isopropanol.

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