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A Review on Composite Liposomal Technologies for Specialized Drug Delivery

2011; Hindawi Publishing Corporation; Volume: 2011; Linguagem: Inglês

10.1155/2011/939851

2090-3014

Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Valence M. K. Ndesendo,

RNA Interference and Gene Delivery

The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology. Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds, there still remain major drawbacks for widespread pharmaceutical application. Two approaches for overcoming the factors related to the suboptimal efficacy of liposomes in drug delivery have been suggested. The first entails modifying the liposome surface with functional moieties, while the second involves integration of pre-encapsulated drug-loaded liposomes within depot polymeric scaffolds. This attempts to provide ingenious solutions to the limitations of conventional liposomes such as short plasma half-lives, toxicity, stability, and poor control of drug release over prolonged periods. This review delineates the key advances in composite technologies that merge the concepts of depot polymeric scaffolds with liposome technology to overcome the limitations of conventional liposomes for pharmaceutical applications.