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Genetic variation in the receptor for advanced glycation end‐products ( RAGE ) gene and ischaemic stroke

2012; Wiley; Volume: 20; Issue: 6 Linguagem: Inglês

10.1111/ene.12041

1468-1331

Staffan Olsson, Katarina Jood,

Cerebrovascular and genetic disorders

Background and purpose The multi‐ligand receptor for a dvanced g lycation e nd‐products ( RAGE , alias AGER ) is suggested to contribute to the pathogenesis of vascular disease, but its potential role in stroke is unclear. The aim of this study was to investigate whether genetic variation in RAGE gene is associated with ischaemic stroke (IS). Methods The S ahlgrenska A cademy S tudy on I schaemic S troke comprises 844 C aucasian patients with first ever ( n = 732) and recurrent ( n = 112) IS, and 668 C aucasian controls. Three tag SNP s were selected to capture genetic variation in the RAGE gene. IS subtypes were determined using TOAST criteria. Results One SNP , rs1035798 , showed significant association with the subtype of small‐vessel disease (SVD) after correction for multiple testing ( OR 1.56, 95% CI 1.16–2.09), adjusted P ‐value < 0.05). This association was independent of hypertension, diabetes and smoking. None of the SNP s was associated with overall IS. Conclusion In this sample of patients with IS, genetic variation in RAGE is associated with the IS subtype SVD, but not overall IS.