Regulation of prostaglandin metabolism: Activation of 15-hydroxyprostaglandin dehydrogenase by chlorpromazine and imipramine related drugs
1976; Elsevier BV; Volume: 68; Issue: 3 Linguagem: Inglês
10.1016/0006-291x(76)91218-3
ISSN1090-2104
AutoresHsin‐Hsiung Tai, Charles S. Hollander,
Tópico(s)Pharmacogenetics and Drug Metabolism
ResumoAbstract Chlorpromazine and imipramine related drugs were found to activate swine renal 15-hydroxprostaglandin dehydrogenase maximally about 2 fold. Activation by these drugs was uncompetitive with respect to both prostaglandin E 1 and NAD+. Hill plots of the rate of reaction against either substrates have a slope of approximately 1, which is not altered by the presence of the activator indicating no cooperativity between the substrate site and putative activator site. Ability of chlorpromazine and imipramine related drugs to activate this enzyme suggests that these drugs may facilitate the inactivation of prostaglandins in vivo .
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