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PATTERNS OF PRESSOR RESPONSE TO NOXIOUS STIMULI IN NORMAL, HYPERTENSIVE, AND DIABETIC SUBJECTS*

1963; American Society for Clinical Investigation; Volume: 42; Issue: 12 Linguagem: Inglês

10.1172/jci104874

1558-8238

Alvin P. Shapiro, Spero E. Moutsos, Emanuel Krifcher,

Olfactory and Sensory Function Studies

In earlier studies, the influence of various host affecting the pressor responses to noxious stimuli in hypertensive and normotensive subjects was investigated. Information was obtained indicating that intrinsic factors predominate in determining the type and severity of such pressor responses (1). It also was demonstrated that lowering basal blood pressure in the hypertensive patient with therapeutic doses of reserpine and chlorothiazide did not decrease these responses (2). The present studies represent a continuing effort to define the factors determining patterns of pressor response to noxious stimuli, with particular attention to the physiologic mechanisms that mediate these responses. As in previous studies, the cold pressor test was assumed to measure the neurogenic component, and this response was