Histories of substance abuse in patients with postpsychotic depressions
1988; Elsevier BV; Volume: 29; Issue: 6 Linguagem: Inglês
10.1016/0010-440x(88)90074-0
ISSN1532-8384
AutoresSamuel G. Siris, Joan M. Kane, Kathleen A Frechen, Ann P. Sellew, John Mandeli, Bernadette Fasano-Dube,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoForty-six schizophrenic or schizoaffective patients with operationally defined episodes of postpsychotic depression were assessed for previous histories of substance abuse. Thirty-five percent had histories of previous cannabis (marijuana) abuse. Additionally, 13% had also abused cocaine, 13% amphetamines, 11% hallucinogens, 4% sedatives, and 2% opiates. Patients with histories of substance abuse were younger and showed higher index ratings on a subscale of endogenous depressive features. These findings are considered in the context of a possible self-medication hypothesis of substance abuse. A history of substance abuse did not appear to be a contraindication to a therapeutic trial of adjunctive imipramine (Ciba Geigy Corp., Summit, NJ) for postpsychotic depression.
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