Oligoclonality in Bladder Cancer:: The Implication for Molecular Therapies
2004; Lippincott Williams & Wilkins; Volume: 171; Issue: 1 Linguagem: Inglês
10.1097/01.ju.0000100105.27708.6c
ISSN1527-3792
AutoresBrian Duggan, Sam B. Gray, JOHN JOSEPH MCKNIGHT, Chris Watson, Samuel Johnston, Kate E. Williamson,
Tópico(s)Ferroptosis and cancer prognosis
ResumoNo AccessJournal of UrologyINVESTIGATIVE UROLOGY: Review Article1 Jan 2004Oligoclonality in Bladder Cancer:: The Implication for Molecular Therapies BRIAN J. DUGGAN, SAM B. GRAY, JOHN J. McKNIGHT, CHRIS J. WATSON, SAMUEL R. JOHNSTON, and KATE E. WILLIAMSON BRIAN J. DUGGANBRIAN J. DUGGAN , SAM B. GRAYSAM B. GRAY , JOHN J. McKNIGHTJOHN J. McKNIGHT , CHRIS J. WATSONCHRIS J. WATSON , SAMUEL R. JOHNSTONSAMUEL R. JOHNSTON , and KATE E. WILLIAMSONKATE E. WILLIAMSON View All Author Informationhttps://doi.org/10.1097/01.ju.0000100105.27708.6cAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: There is conflicting evidence in the published literature regarding the clonal or oligoclonal origin of bladder cancer. Materials and Methods: A MEDLINE search of articles on the clonality, genetic, epigenetic and tumor microenvironment of bladder cancer cells was done. Laboratory and clinical studies were included and relevant articles were selected if tumor cell clonality was part of the study. We reviewed this published evidence. Results: Current thinking proposes 2 main theories. 1) In the clonogenic theory multifocal and recurrent tumors evolve from a single transformed cell and, hence, all progeny share a number of identical genetic mutations. 2) The field change theory assumes a global change in the urothelium with multiple transformed cells evolving into mature tumors independently. The evidence for and against each theory is compelling. Of equal importance are the parallel epigenetic modifications and changes in the cellular microenvironment that permit tumor evolution. Conclusions: The presence of oligoclonality has implications for the potential efficacy of novel molecular therapeutic agents for bladder cancer. The molecular targets for such therapies must be widely sampled in a tumor population to assess expression in separate clones. 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Abstract, Google Scholar From the Department of Urology, Belfast City Hospital (BJD, SRJ) and Uro-oncology Group, Queen's University Belfast, (SBG, JJM, KEW), Belfast, Northern Ireland© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byRyk C, Steineck G, Wiklund N, Nyberg T and de Verdier P (2010) The (CCTTT)n Microsatellite Polymorphism in the Nitric Oxide Synthase 2 Gene May Influence Bladder Cancer PathogenesisJournal of Urology, VOL. 184, NO. 5, (2150-2157), Online publication date: 1-Nov-2010.Grimm M and Ackermann R (2018) TRANSURETHRAL RESECTION OF SUPERFICIAL BLADDER CANCER: TECHNICALLY SAFE, ONCOLOGICALLY ANYTHING BUT PERFECTJournal of Urology, VOL. 174, NO. 6, (2086-2087), Online publication date: 1-Dec-2005. Volume 171 Issue 1 January 2004 Page: 419-425 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordsbladderbladder neoplasmscarcinoma, transitional cellgene expressionclone cellsMetrics Author Information BRIAN J. DUGGAN More articles by this author SAM B. GRAY More articles by this author JOHN J. McKNIGHT More articles by this author CHRIS J. WATSON More articles by this author SAMUEL R. JOHNSTON More articles by this author KATE E. WILLIAMSON More articles by this author Expand All Advertisement PDF downloadLoading ...
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