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Physicochemical Stability of NOX-E36, a 40mer L-RNA (Spiegelmer) for Therapeutic Applications

2008; Oxford University Press; Volume: 52; Issue: 1 Linguagem: Inglês

10.1093/nass/nrn031

1746-8272

Christian Maasch, Klaus Buchner, Dirk Eulberg, Stefan Vonhoff, JP Klußmann,

Radiopharmaceutical Chemistry and Applications

Spiegelmers are structured mirror-image oligonucleotides that are designed to bind and inhibit pharmacologically relevant target molecules. The synthesis and purification of mirror-image oligonucleotides is comparable to the manufacturing of standard oligonucleotides that consist of naturally configured nucleotides. Due to the use of the non-natural L-nucleotides in Spiegelmers, these oligonucleotides show an exceptional biostability. Further, they also display a high physicochemical stability in solution. These properties make them interesting substances for drug development.