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Comparison of three protracted antiemetic regimens for the control of delayed emesis in cisplatin-treated patients

1992; Elsevier BV; Volume: 28; Issue: 8-9 Linguagem: Inglês

10.1016/0959-8049(92)90515-4

1879-0852

Isabel Moreno, Rafael Rosell, Albert Abad, Agustí Barnadas, Joan Carles, Nuria Ribelles, V. Solano, Albert Font,

Nausea and vomiting management

Antiemetic activity of three protracted regimens for the control of cisplatin-evoked delayed emesis was explored. 63 patients were randomly assigned to receive one of three protracted antiemetic schedules over 4 days. Group C patients received dexamethasone 8 mg twice daily on days 2 and 3, then 4 mg twice daily on days 4 and 5; in group B, alizapride 2.5 mg/kg four times daily on days 2–5 plus dexamethasone as in group C was administered; and in group A, metoclopramide 0.5 mg/kg four times daily on days 2–5 plus dexamethasone was given at the same dose-schedule as in groups C and B. Complete protection from delayed vomiting was achieved in 44% of group C, 30% of B and 70% of group A (P = 0.02). Mild side-effects were noted in all three groups. A higher complete protection for delayed emesis was obtained in metoclopramide-dexamethasone-treated patients. Neither of the regimens used in the protection of delayed emesis controlled late nausea.