Portal de Periódicos da CAPES

ALTERED REMOVAL OF VASOACTIVE SUBSTANCES IN THE INJURED LUNG: DETECTION OF LUNG MICROVASCULAR INJURY*

1982; Wiley; Volume: 384; Issue: 1 Linguagem: Inglês

10.1111/j.1749-6632.1982.tb21392.x

1749-6632

C. N. Gillis, John D. Catravas,

Respiratory Support and Mechanisms

Annals of the New York Academy of SciencesVolume 384, Issue 1 p. 458-474 Full Access ALTERED REMOVAL OF VASOACTIVE SUBSTANCES IN THE INJURED LUNG: DETECTION OF LUNG MICROVASCULAR INJURY* C. Norman Gillis, C. Norman Gillis Departments of Anesthesiology and Pharmacology Yale University School of Medicine New Haven, Connecticut 06511Search for more papers by this authorJohn D. Catravas, John D. Catravas Departments of Anesthesiology and Pharmacology Yale University School of Medicine New Haven, Connecticut 06511Search for more papers by this author C. Norman Gillis, C. Norman Gillis Departments of Anesthesiology and Pharmacology Yale University School of Medicine New Haven, Connecticut 06511Search for more papers by this authorJohn D. Catravas, John D. Catravas Departments of Anesthesiology and Pharmacology Yale University School of Medicine New Haven, Connecticut 06511Search for more papers by this author First published: May 1982 https://doi.org/10.1111/j.1749-6632.1982.tb21392.xCitations: 46 * Work from the author's laboratory was supported in part by Grants No. HL 13315, HL 22244, HL 07410, and HL 23245 from the National Heart, Lung and Blood Institute, National Institutes of Health. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Petty, T. L. & D. G. Ashbauch. 1971. The adult respiratory distress syndrome: clinical features, factors influencing prognosis and principles of management. Chest 60: 233–239. 2 Gillis, C. N. 1973. Metabolism of vasoactive hormones by lung. Anesthesiology 39: 626–632. 3 Gillis, C. N. & B. R. Pitt. 1982. The fate of circulating amines within the pulmonary circulation. Ann. Rev. Physiol. 44: 269–281. 4 Flink, J. R., B. R. Pitt, G. L. Hammond & C. N. Gillis. 1982. Selective effects of microembolization on pulmonary removal of biogenic amines. J. Appl. Physiol 52: 421–427. 5 Iwasawa, Y. & C. N. Gillis. 1974. Pharmacological analysis of norepinephrine and 5-hydroxytryptamine removal from the pulmonary circulation: differentiation of uptake siles-for each amine. J. Pharmacol. Exp. Ther. 188: 386–393. 6 Iwasawa, Y., C. N. Gillis & C. Aghajanian. 1973. Hypothermic inhibition of 5-hydroxytryptamine and norepinephrine uptake by lung: cellular location of amines after uptake. J. Pharmacol. Exp. Ther. 186: 498–507. 7 Junod, A. F. 1975. Metabolism, production and release of hormones and mediators in the lung. Am. Rev. Respir. Dis. 112: 93–108. 8 Ryan, U. S., C. Whitaker & A. Chiu. 1976. Location of angiotensin converting enzyme (kininase II]. II. Immunocytochemistry and immunofluorescence. Tissue Cell 8: 125–145. 9 Caldwell, P. R., B. C. Seegal, K. C. Hsu, M. Das & R. L. Soffer. 1976. Angiotensin converting enzyme: vascular endothelial localization. Science 191: 1050–1051. 10 Hammond, G. L., L. H. Cronau, D. Whiitaker & C. N. Gillis. 1977. Fate of prostaglandins E1 and A2 in the human pulmonary circulation. Surgery 81: 716–722. 11 Gillis, C. N., L. H. Cronau, S. Mandel & G. L. Hammond. 1979. Indicator dilution measurement of 5-hydroxytryptamine clearance by human lung. J. Appl. Physiol. 46: 1178–1183. 12 Block, E. R. & A. B. Fisher. 1977. Depression of serotonin clearance by rat lung during oxygen exposure. J. Appl. Physiol. 42: 33–38. 13 Catravas, J. D. & C. N. Gillis. 1980. Pulmonary clearance of 14C-5-hydroxytryptamine and 3H-norepinephrine in vivo: effects of pretreatment with imipramine or cocaine. J. Pharmacol. Exp. Ther. 213: 120–127. 14 Pitt, B. R., C. N. Gillis & G. L. Hammond. 1981. The influence of lung on arterial levels of prostaglandins E and F. J. Appl. Physiol. 50: 1161–1167. 15 Ryan, J. W., A. Chung, L. C. Martin & U. S. Ryan. 1978. New substrates for the radioassay of angiotensin converting enzyme of endothelial cells in culture. Tissue Cell 10: 555–562. 16 Crooke, S. T. & W. T. Bradner 1976. Bleomycin. a review. J. Med. 7: 333–428. 17 Catane, R., J. G. Schwade, A. T. Turrisi, B. L. Webber & F. M. Muggia. 1979. Pulmonary toxicity after radiation and bleomycin: a review. Int. J. Radiat. Oncol. Biol. Phys. 5: 1513–1519. 18 Catravas, J. D., J. S. Lazo & C. N. Gillis. 1981. Biochemical markers of bleomycin toxicity: clearance of 14C-5-hydroxytryptamine and 3H-norepinephrine by rabbit lung in vivo. J. Pharmacol Exp. Ther. 217: 524–529. 19 Lazo, J. S., J. D. Catravas & C. N. Gillis. 1981. Serum and pulmonary angiotensin converting enzyme activity in rabbit after bleomycin treatment. Biochem. Pharmacol. 30: 2577–2584. 20 Valdivia, E., J. J. Lalich, Y. Hayashi & J. Sonnad. 1967. Alterations in pulmonary alveoli after a single injection of monocrotaline. Arch. Pathol. 84: 64–76. 21 Gillis, C. N., R. J. Huxtable & R. A. Roth. 1978. Effects of monocrotaline pretreatment of rats on removal of 5-hydroxytryptamine and noradrenaline by perfused lungs. Br. J. Pharmacol. 63: 435–443. 22 Huxtable, R. I., D. Ciaramituro & D. Eisenstein. 1978. The effects of a pyrrolizidine alkaloid, monocrotaline, and a pyrrole, dehydroretronecine, on the biochemical functions of the pulmonary endothelium. Mol. Pharmacol. 14: 1189–1203. 23 Vijeyoratnam, G. S. & B. Corrin. 1971. Experimental paraquat poisoning: a histological and electron-optical study of the changes in the lung. J. Pathol. 103: 123–129. 24 Roth, R. A., K. B. Wallace, R. H. Alper & M. D. Bailie. 1979. Effect of paraquat treatment of rats on disposition of 5-hydroxytryptamine and angiotensin by perfused lung. Biochem. Pharmacol. 28: 2349–2355. 25 Ratliff, N. B., W. G. Young, D. B. Hackel, E. Mikat & J. W. Wilson. 1973. Pulmonary injury secondary to extracorporeal circulation. J. Thorac. Cardiovasc. Surg. 65: 425–432. 26 Pitt B. R., G. L. Hammond & C. N. Gillis. 1982. Depressed pulmonary removal of 3H-PGE1 after prolonged cardiopulmonary bypass. J. Appl. Physiol. 52. (In press.). 27 Kistler, G. S., P. R. B. Caldwell & E. R. Weibel. 1957. Development of fine structural damage to alveolar and capillary lining cells in oxygen poisoned rat lungs. J. Cell Biol. 33: 605–628. 28 Fisher, A. B., E. R. Block & G. Pietra. 1980. Environmental influences on uptake of serotonin and other amines. Environ. Health Perspect. 35: 191–198. 29 Klein, L. S., A. B. Fisher, S. Soltoff & R. F. Coburn. 1978. Effect of O2 exposure on pulmonary metabolism of prostaglandin E2, Am. Rev. Respir. Dis. 118: 622–625. 30 Catravas, J. D. & C. N. Gillis. 1981. Metabolism of 3H-benzoyl-phenylalanylalanyl-proline by pulmonary angiotensin converting enzyme, in vivo: effects of bradykinin. SQ14225 or acute hypoxia. J. Pharmacol. Exp. Ther. 217: 263–270. 31 Dobuler, K. J., J. D. Catravas & C. N. Gillis. 1982. Hyperoxic lung injury and altered metabolic functions in conscious rabbits. Am. Rev. Respir. Dis. (Submitted.). 32 Bedrossian, C. W. M., J. Woo, W. C. Miller & D. C. Cannon. 1978. Decreased angiotensin-converting enzyme in the adult respiratory distress syndrome. Am. J. Clin. Pathol. 70: 244–247. 33 Conners, A. F., D. R. McCaffree & R. M. Rogers. 1981. The Adult Respiratory Distress Syndrome. 27 (4). Year Book Medical Publishers, Inc. Chicago , Ill . 34 Gillis, C. N. 1982. Pulmonary removal of vasoactive substances in vivo. Fed. Proc. (In press.). 35 Gillis, C. N. & J. A. Roth. 1976. Pulmonary disposition of circulating vasoactive hormones. Biochem. Pharmacol. 25: 2547–2553. 36 Giri, S. N., M. A. Hollinger & M. J. Schiedt. 1980. The effects of ozone and paraquat on PGF2α and PGE2 levels in plasma and combined pleural effusion and lung lavage in rats. Environ. Res. 21: 467–476. 37 Crapo, J. D., B. E. Barry, H. A. Foscue & J. Shelburne. 1980. Structural and biochemical changes in rat lungs occurring during exposure to lethal and adaptive doses of oxygen. Am. Rev. Respir. Dis. 122: 123–143. 38 Molteni, A., N. Solliday, W. F. Ward, C. D. Port & N. Remus. 1981. Angiotensin converting enzyme (ACE) activity in irradiated rat lung. Fed. Proc. 40: 791. 39 Chaudyri, A. & S. Dutta. 1980. Effects of acute exposure of guinea pigs to NO2 on pulmonary prostaglandin dehydrogenase and angiotensin converting enzyme. Bull. Environ. Contam. Toxicol. 25: 816–823. 40 Block, E. R. & F. J. Schoen. 1981. Effect of alpha naphthylthiourea on uptake of 5-hydroxytryptamine from the pulmonary circulation. Am. Rev. Respir. Dis. 123: 69–73. 41 Block, E. R., G. Ryerson, J. O. Harris & J. K. Cannon 1979. Effect of pulmonary emphysema on 5-hydroxytryptamine (5-HT) uptake by hamster lungs. Am. Rev. Respir. Dis. 119: 290. 42 Stalcup, S. A., P. J. Leuenberger, J. S. Lipset, M. M. Osman, J. M. Cerreta, R. B. Mellins & G. M. Turino. 1981. Impaired angiotensin conversion and bradykinin clearance in experimental canine pulmonary emphysema. J. Clin. Invest. 67: 201–209. 43 Hollinger, M. A., S. N. Giri, S. Patwell, J. E. Zuckerman, A. Gorin & G. Parsons. 1980. Effects of acute lung injury on angiotensin converting enzyme in serum, lung lavage and effusate. Am. Rev. Respir. Dis. 121: 373–376. 44 Sole, M. J., M. Drobac, L. Schwartz, M. N. Hussain & E. F. Vaughan-Neil. 1979. The extraction of circulating catecholamines by the lungs of normal man and patients with pulmonary hypertension. Circulation 60: 160–163. 45 Pitt, B. R. & G. Lister. 1982. Kinetics of angiotensin-converting enzyme (ACE) in the conscious newborn lamb. Fed. Proc. (In press.). Citing Literature Volume384, Issue1Mechanisms of Lung Microvascular InjuryMay 1982Pages 458-474 ReferencesRelatedInformation