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Asymmetric synthesis of novel α-amino acids with β-branched side chains

2007; Elsevier BV; Volume: 17; Issue: 9 Linguagem: Inglês

10.1016/j.bmcl.2007.02.041

1464-3405

Minsheng Zhang, Alex Porte, George Diamantidis, Kimberly Sogi, Dennis Kubrak, Lynn Resnick, Scott C. Mayer, Zheng Wang, Anthony F. Kreft, Boyd L. Harrison,

Analytical Chemistry and Chromatography

An asymmetric synthesis of alpha-amino acids with novel beta-branched side chains has been implemented. The syntheses feature a p-toluenesulfinylimine induced chiral Strecker approach and were found to be applicable to the introduction of both aliphatic and aromatic beta-branched sidechains for preparation of previously unknown alpha-amino acids.