Strong male bias drives germline mutation in chimpanzees
2014; American Association for the Advancement of Science; Volume: 344; Issue: 6189 Linguagem: Inglês
10.1126/science.344.6189.1272
ISSN1095-9203
AutoresOliver Venn, Isaac Turner, Iain Mathieson, Natasja M.S. de Groot, Ronald E. Bontrop, Gil McVean,
Tópico(s)Genomics and Chromatin Dynamics
ResumoGermline mutation determines rates of molecular evolution, genetic diversity, and fitness load. In humans, the average point mutation rate is 1.2 × 10(-8) per base pair per generation, with every additional year of father's age contributing two mutations across the genome and males contributing three to four times as many mutations as females. To assess whether such patterns are shared with our closest living relatives, we sequenced the genomes of a nine-member pedigree of Western chimpanzees, Pan troglodytes verus. Our results indicate a mutation rate of 1.2 × 10(-8) per base pair per generation, but a male contribution seven to eight times that of females and a paternal age effect of three mutations per year of father's age. Thus, mutation rates and patterns differ between closely related species.
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