Portal de Periódicos da CAPES

Stem cells in retinal regeneration: past, present and future

2013; The Company of Biologists; Volume: 140; Issue: 12 Linguagem: Inglês

10.1242/dev.092270

1477-9129

Conor M. Ramsden, Michael B. Powner, Amanda‐Jayne F. Carr, Matthew Smart, Lyndon da Cruz, Peter Coffey,

Pluripotent Stem Cells Research

Stem cell therapy for retinal disease is under way, and several clinical trials are currently recruiting. These trials use human embryonic, foetal and umbilical cord tissue-derived stem cells and bone marrow-derived stem cells to treat visual disorders such as age-related macular degeneration, Stargardt's disease and retinitis pigmentosa. Over a decade of analysing the developmental cues involved in retinal generation and stem cell biology, coupled with extensive surgical research, have yielded differing cellular approaches to tackle these retinopathies. Here, we review these various stem cell-based approaches for treating retinal diseases and discuss future directions and challenges for the field.