Portal de Periódicos da CAPES

Effect of Tilia cordata flower on lymphocyte proliferation: participation of peripheral type benzodiazepine binding sites

1999; Elsevier BV; Volume: 70; Issue: 4 Linguagem: Inglês

10.1016/s0367-326x(99)00049-0

1873-6971

Claudia Anesini, Silivia Werner, Enri Borda,

Biochemical Analysis and Sensing Techniques

The aqueous extract of Tilia cordata flowers showed in vitro stimulatory effects on lymphocyte proliferation (maximum stimulatory concentration: 20 μg/ml). This effect was mimicked by Ro 5-4864, an agonist of the peripheral benzodiazepine receptor, and by Pk 11195, an agonist/antagonist of the same receptor. These results suggest that Tilia extract could exert its stimulatory effect acting as an agonist of the peripheral benzodiazepine receptor.