Modulation of Somaninduced neuropathology with an anticonvulsant regimen
1994; Lippincott Williams & Wilkins; Volume: 5; Issue: 17 Linguagem: Inglês
10.1097/00001756-199411000-00015
ISSN1473-558X
AutoresGuy Lallement, Irmine Pernot-Marino, Dominique Baubichon, Marie‐France Burckhart, Pierre Carpentier, Guy Blanchet,
Tópico(s)Immunotoxicology and immune responses
ResumoRat hippocampus and piriform cortex were examined for pathological changes 48 hours after exposure to a convulsant dose of soman. Animals were treated with a low dose of atropine just after soman and were then injected, after 10 or 40 minutes of seizures, with both the anticonvulsant drugs NBQX and TCP. Atropine given alone counteracted the extensive neuronal loss due to soman in both areas without prevention of neuronal suffering. Comparatively, the complete anticonvulsant regimen, given before 40 minutes of seizures, totally prevented hippocampal soman-induced neuropathology. Neurones of piriform cortex were still suffering whatever the time of injection of the drugs. This emphasizes the need for a rapid and definitive anticonvulsant treatment just after soman intoxication to block the subsequent neurotoxic effect of nerve-agent exposure.
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