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Insulin signalling: the role of insulin receptor substrate 1

1994; Elsevier BV; Volume: 4; Issue: 4 Linguagem: Inglês

10.1016/0962-8924(94)90065-5

1879-3088

Susanne R. Keller, Gustav E. Lienhard,

PI3K/AKT/mTOR signaling in cancer

The insulin receptor is a ligand-activated tyrosine kinase that phosphorylates its major substrate protein, insulin receptor substrate 1 (IRS1), at multiple sites. Tyrosine-phosphorylated IRS1 then serves as a docking/effector protein for at least four Src homology 2 (SH2)-domain proteins involved in signal transduction. This initial step in signalling distinguishes the insulin receptor from other receptor tyrosine kinases, which directly bind several SH2-domain proteins, and establishes IRS1 as a founding member of a group of proteins whose function is to link activated tyrosine kinases to SH2-domain proteins.