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Acute oral toxicity of Pereskia bleo and Pereskia grandifolia in mice

2010; SAGE Publishing; Volume: 6; Issue: 21 Linguagem: Inglês

10.4103/0973-1296.59969

0976-4062

AM Sri Nurestri, SK Sinniah, KH Kim, AW Norhanom, Kae Shin Sim,

Botanical Research and Applications

Pharmacognosy Magazine,2010,6,21,67-70.DOI:10.4103/0973-1296.59969Published:February 2010Type:Original ArticleAuthors:KS Sim, AM Sri Nurestri, SK Sinniah, KH Kim, and AW Norhanom Author(s) affiliations:KS Sim1, AM Sri Nurestri1, SK Sinniah1, KH Kim2, AW Norhanom3 1 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia 3 Center for Foundation Studies in Science, University of Malaya, 50603 Kuala Lumpur, Malaysia Abstract:Pereskia bleo and Pereskia grandifolia, belonging to the botanical family Cactaceae, have been traditionally used by the locals in Malaysia for treatment of various ailments. The current study reports the outcome of acute oral toxicity investigation of Pereskia bleo and Pereskia grandifolia, on ICR mice. No mortalities or evidence of adverse effects have been observed in ICR mice following acute oral administration at the highest dose of 2500 mg/ kg crude extracts of Pereskia bleo and Pereskia grandifolia. This is the first report on the acute oral toxicity of Pereskia bleo and Pereskia grandifolia and the findings of this study are in agreement with those of in vitro experiments and thus provide scientific validation on the use of the leaves of Pereskia bleo and Pereskia grandifolia. Keywords:Acute oral toxicity, Cactaceae, Pereskia bleo, Pereskia grandifoliaView:PDF (639.09 KB) Full Text