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Comparison of Low-Intensity Warfarin Therapy with Conventional-Intensity Warfarin Therapy for Long-Term Prevention of Recurrent Venous Thromboembolism

2003; Massachusetts Medical Society; Volume: 349; Issue: 7 Linguagem: Inglês

10.1056/nejmoa035422

1533-4406

Clive Kearon, Jeffrey S. Ginsberg, Michael J. Kovacs, David R. Anderson, Philip Wells, Jim A. Julian, Betsy MacKinnon, Jeffrey I. Weitz, Mark Crowther, Sean Dolan, Alexander G.G. Turpie, William Geerts, Susan Solymoss, Paul Nguyen, Christine Demers, Susan R. Kahn, Jeannine Kassis, Marc Rodger, Julie Hambleton, Michael Gent,

Blood Coagulation and Thrombosis Mechanisms

Warfarin is very effective in preventing recurrent venous thromboembolism but is also associated with a substantial risk of bleeding. After three months of conventional warfarin therapy, a lower dose of anticoagulant medication may result in less bleeding and still prevent recurrent venous thromboembolism.