Field-adapted method for high-performance thin-layer chromatographic detection and estimation of chloroquine in finger-stick blood
1988; Elsevier BV; Volume: 428; Linguagem: Inglês
10.1016/s0378-4347(00)83908-0
ISSN1872-812X
AutoresDwight L. Mount, Leslie C. Patchen, Frederick C. Churchill,
Tópico(s)Poisoning and overdose treatments
ResumoA suicidal ingestion of an unknown quantity of Resochin® (chloroquine) tablets is described. Although chloroquine is known since 1934, intoxications due to chloroquine overdose are rather rare in European countries. The authors report on a new and fast method of analysing and determining the chloroquine concentration in body fluids and postmortem specimens. The analytes were extracted from alkalinized samples into ethyl acetate before GC/MS analysis. The analyses of chloroquine were performed without any complex sample clean-up steps and, in addition, with little sample material. The proposed method resulted in a rapid procedure most useful in cases of deliberate poisoning with the anti-inflammatory and antimalarial drug chloroquine.
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