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Asymmetric synthesis of trans- β -lactams through TiCl4-mediated addition to imines.

1987; Elsevier BV; Volume: 28; Issue: 2 Linguagem: Inglês

10.1016/s0040-4039(00)95693-4

1873-3581

Cesare Gennari, I. VENTURINI, Gabriele Gislon, Giuliana Schimperna,

Synthesis and Catalytic Reactions

TiCl4-mediated addition of the chiral silyl ketene acetal (2) to benzylideneaniline proceeds with high stereoselectivity to give, after cyclization, trans- β -lactam (7) in good yield and 95% e.e.