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Results of Screening, Rescreening, and Follow-up in a Prospective Randomized Study for Detection of Colorectal Cancer by Fecal Occult Blood Testing: Results for 68,308 Subjects

1994; Taylor & Francis; Volume: 29; Issue: 5 Linguagem: Inglês

10.3109/00365529409096840

1502-7708

J Kewenter, Hans Brevinge, Boel Engarås, E. Haglind, C. Åhrén,

Colorectal Cancer Treatments and Studies

All 68.308 inhabitants of Goteborg born between 1918 and 1931 were randomly divided into a test and a control group. The subjects in the test group were invited to perform Hemoccult II fecal occult blood testing on 3 days and to repeat the test after 16 to 24 months. In the prevalence screening 21,347 (63%) performed the test, and in the rescreening 19.991 (60%). Investigation of the 942 (4.4%) with positive tests in the prevalence screening showed 47 cancers and 129 subjects with adenomas ≥1.0 cm. In the rescreening 5.1% had a positive test, and 34 cancers and 122 subjects with adenomas ≥1.0cm) were found among those. Cancer had also been diagnosed in 19 subjects in the interval between the two screening occasions and in 15 subjects among the non-responders. Forty-four cancers had been diagnosed in the control group during the same period. Cancers detected by screening were at a less advanced stage than in the control group. It is too early to show any effect of screening on mortality from colorectal cancer.