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Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

2014; American Association for the Advancement of Science; Volume: 343; Issue: 6175 Linguagem: Inglês

10.1126/science.1246980

1095-9203

Mark N. Lee, Chun Ye, Alexandra‐Chloé Villani, Towfique Raj, Weibo Li, Thomas Eisenhaure, Selina Imboywa, Portia Chipendo, F. Ann Ran, Kamil Slowikowski, Lucas D. Ward, Khadir Raddassi, Cristin McCabe, Michelle Lee, Irene Y. Frohlich, D Hafler, Manolis Kellis, Soumya Raychaudhuri, Feng Zhang, Barbara E. Stranger, Christophe Benoist, Philip L. De Jager, Aviv Regev, Nir Hacohen,

Immune Response and Inflammation

Immune Variation It is difficult to determine the mechanistic consequences of context-dependent genetic variants, some of which may be related to disease (see the Perspective by Gregersen ). Two studies now report on the effects of stimulating immunological monocytes and dendritic cells with proteins that can elicit a response to bacterial or viral infection and assess the functional links between genetic variants and profiles of gene expression. M. N. Lee et al. ( 10.1126/science.1246980 ) analyzed the expression of more than 400 genes, in dendritic cells from 534 healthy subjects, which revealed how expression quantitative trait loci (eQTLs) affect gene expression within the interferon-β and the Toll-like receptor 3 and 4 pathways. Fairfax et al. ( 10.1126/science.1246949 ) performed a genome-wide analysis to show that many eQTLs affected monocyte gene expression in a stimulus- or time-specific manner.