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UDP-glucuronosyltransferases: a family of detoxifying enzymes

1990; Elsevier BV; Volume: 11; Issue: 7 Linguagem: Inglês

10.1016/0165-6147(90)90008-v

1873-3735

Thomas R. Tephly, Brian Burchell,

Alcohol Consumption and Health Effects

Glucuronidation is an important process in the metabolism of xenobiotic and endogenous substances leading to enhancement of excretion of these compounds from the body. A multigene family encodes a number of UDP-glucuronosyltransferase enzymes which catalyse this route of metabolism. Recent advances in biochemical and molecular biological approaches, reviewed here by Thomas Tephly and Brian Burchell, have given new insight into the function and structure of UDP-glucuronosyltransferases. These proteins have surprising similarities and yet appear to be capable of conjugating a remarkable number of different chemicals.