Amygdaloid kindling during rapid eye movement (REM) sleep in cats
1982; Elsevier BV; Volume: 29; Issue: 3 Linguagem: Inglês
10.1016/0304-3940(82)90326-3
ISSN1872-7972
AutoresJosé María Calvo, Raúl Alvarado, Rafael Briones, Carlos Paz, Augusto Fernández‐Guardiola,
Tópico(s)Epilepsy research and treatment
ResumoDevelopment of amygdaloid kindling was analyzed during REM sleep and during wakefulness. Daily evolution of electrographic and behavioral changes was significantly delayed in REM kindled rats. The number of kindling trials required to reach the first generalized convulsive seizure was also significantly increased in comparison with awake kindled animals. Changes in sleep organization were measured under REM kindling conditions. A significant increase in total sleep time and in the percentage of light slow-wave sleep was found during the kindling process. No significant sleep changes were observed in REM-established kindling. REM inhibitory influence over epileptogenesis is discussed.
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