Lymphocyte infiltration and prognosis in colorectal cancer
2009; Elsevier BV; Volume: 10; Issue: 9 Linguagem: Inglês
10.1016/s1470-2045(09)70245-1
ISSN1474-5488
Autores Tópico(s)Colorectal Cancer Surgical Treatments
ResumoFor the clinical management of colorectal cancer and selection of patients for adjuvant therapy, it is essential to assess the risk of disease recurrence and metachronous metastasis at the time of diagnosis. The tumour–node–metastasis (TNM) staging system, which refers to the local expansion of the tumour, involvement of lymph nodes, and the presence of metastases to distant organs, has been established as the best available means to make therapeutic decisions in patients with colorectal cancer. CD3+ cells at the invasive margin of deeply invading (pT3–T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal studyMetachronous metastases are unlikely to arise from node-negative colorectal cancers with a high-density CD3+ TILIM, whereas high densities of CD3+ TILIM are not associated with the absence of postsurgical metastasis in patients with node-positive colorectal cancer. Our data suggest that densities of CD3+ TILIM cannot be used as an independent predictor of clinical outcome in patients with stage III colorectal cancer and, at least for now, the tumour-node-metastasis classification should remain the preferred prognostic system. Full-Text PDF
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