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Possible role of T cells in the establishment of IgG plasma cell‐rich periodontal lesion –Augmentation of IgG synthesis in the polyclonal B cell activation response by autoreactive T cells

1988; Wiley; Volume: 23; Issue: 1 Linguagem: Inglês

10.1111/j.1600-0765.1988.tb01025.x

1600-0765

Hiro‐O Ito, Yasushi Harada, Takashi Matsuo, Shigeyuki Ebisu, Hiroshi Okada,

Immunotherapy and Immune Responses

The effect of T cells on T‐independent polyclonal B cell activation (PBA) was studied in vitro in mice. Helper/inducer T cells were activated by interaction with la antigens expressed on B cells. The activated T cells enhanced IgG synthesis in the PBA reaction. la antigen expression on B cells increased when stimulated by polyclonal B cell activators. An autoreactive T cell line was established by longterm culture of spleen cells with polyclonal B cell activators. The culture supernatant from this autoreactive T cell line enhanced IgG synthesis in PBA. The above results suggest that autoreactive T cells were activated by la expressed on B cells stimulated with polyclonal B cell activators, and then prompted B cells to synthesize IgG. Therefore, autoreactive T cells may play an important role in the establishment of the IgG plasma cell‐rich periodontal lesion.