Duodenal Ulcer Treated with Omeprazole: Healing and Relapse Rates
1989; Taylor & Francis; Volume: 24; Issue: 9 Linguagem: Inglês
10.3109/00365528909089263
ISSN1502-7708
AutoresPer G. Farup, Arne R. Rosseland, Lars Halvorsen, O. K. Andersen, T. Bernklev,
Tópico(s)Gastric Cancer Management and Outcomes
ResumoAbstractOne hundred and twenty-nine patients were studied with regard to healing of duodenal ulcers with 30 mg omeprazole once daily, recurrence rates after 2 and 4 weeks' treatment in patients with ulcers healed after 2 weeks, and recurrences in rapid and slow healers. Cumulative healing rates were 77% and 98% after 2 and 4 weeks, respectively. Eighty-one patients (65%) were without ulcer symptoms after 2 weeks, and 43 (34%) were improved. Seven of 45 patients (16%; 95% confidence limits, 6-30%) with ulcers healed after 2 weeks had relapsed after another 2 weeks of placebo; 3 were asymptomatic. The overall relapse rate after 6 months was 62%. There were no statistically significant differences in relapse rates between 2 and 4 weeks″ treatment of patients with ulcers healed after 2 weeks or between rapid and slow healers. Ulcer size, smoking habits, and alcohol consumption were not significantly related to healing or relapse.Key Words: Clinical trialduodenal ulceromeprazolerelapse ratesubstituted benzimidazole
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