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Studies on effect of pH on cross-linking of chitosan with sodium tripolyphosphate: A technical note

2006; Springer Science+Business Media; Volume: 7; Issue: 2 Linguagem: Inglês

10.1208/pt070250

1530-9932

Devika R. Bhumkar, Varsha Pokharkar,

Polymer Surface Interaction Studies

The ionotropic gelation method for formation of crosslinked chitosan particles can be easily modified from ionic cross-linking to deprotonation by adjusting the pH of TPP. Chitosan was cross-linked ionically with TPP at lower pH and by deprotonation mechanism at higher pH. The swelling behavior of cross-linked chitosan appeared to depend on the pH of TPP. The ionically cross-linked chitosan showed higher swelling ability. Thus the nature of crosslinked chitosan can be tailor made to obtain the desired properties in terms of cross-linking density, crystallinity, and hydrophilicity.