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Synthesis and anti-HIV activity of pyrrolo-[1,2-d]-(1,4)-benzodiazepin-6-ones

1992; Elsevier BV; Volume: 2; Issue: 12 Linguagem: Inglês

10.1016/s0960-894x(00)80447-3

1464-3405

George V. De Lucca, Michaël Otto,

Biochemical and Molecular Research

The synthesis of novel pyrrolo annulated 1,4-benzodiazepines is described. These pyrrolo[1,2-d]-(1,4)-benzodiazepines have been found to have antiviral activity against HIV-1. Like other non nucleoside HIV-1 RT inhibitors, these compounds appear to be specific for HIV-1.