DNA adducts as biomarkers in genotoxic risk assessment in the aquatic environment
1989; Elsevier BV; Volume: 28; Issue: 1-4 Linguagem: Inglês
10.1016/0141-1136(89)90253-5
ISSN1879-0291
AutoresBranko Kurelec, Achal Garg, Sanja Krča, Ramesh C. Gupta,
Tópico(s)Environmental Toxicology and Ecotoxicology
ResumoThe presence of ‘natural’ (‘pre-existing’) DNA adducts in indicator organisms may complicate the use of pollution-related DNA-adduct measurements as a biomarker in the assessment of both the biologically relevant exposure to carcinogens and the pathobiological consequences of that exposure. Here, we present data demonstrating that detection and identification of exposure-related DNA adducts in marine and freshwater organisms (sponge, mussel and fish) is possible despite the presence, sometimes, of great numbers and significant levels of natural DNA adducts.
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