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ASSOCIATION OF HEMOSPERMIA WITH PROSTATE CANCER

2004; Lippincott Williams & Wilkins; Volume: 172; Issue: 6 Part 1 Linguagem: Inglês

10.1097/01.ju.0000144565.76243.b1

1527-3792

Misop Han, Robert E. Brannigan, Jo Ann V. Antenor, Kimberly A. Roehl, William J. Catàlona,

Prostate Cancer Diagnosis and Treatment

No AccessJournal of UrologyAdult Urology: Oncology:Prostate/Testis/Penis/Urethra1 Dec 2004ASSOCIATION OF HEMOSPERMIA WITH PROSTATE CANCER MISOP HAN, ROBERT E. BRANNIGAN, JO ANN V. ANTENOR, KIMBERLY A. ROEHL, and WILLIAM J. CATALONA MISOP HANMISOP HAN , ROBERT E. BRANNIGANROBERT E. BRANNIGAN , JO ANN V. ANTENORJO ANN V. ANTENOR , KIMBERLY A. ROEHLKIMBERLY A. ROEHL , and WILLIAM J. CATALONAWILLIAM J. CATALONA View All Author Informationhttps://doi.org/10.1097/01.ju.0000144565.76243.b1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Hemospermia is uncommon clinical condition that usually follows a benign course. The association between hemospermia and prostate cancer has been reported but to our knowledge not thoroughly investigated. We studied the incidence of hemospermia and the association between prostate cancer and hemospermia in a large prostate cancer screening population. Materials and Methods: Between 1991 and 2001, 26,126 ambulatory men 50 years or older (40 years or older with a family history of prostate cancer or black race) underwent a community based prostate cancer screening study using serum prostate specific antigen (PSA) and digital rectal examination (DRE). PSA measurement and DRE were repeated at 6-month or 1-year intervals depending on PSA for the remainder of the study. Men underwent prostate biopsy due to increased serum PSA (greater than 4.0 ng/ml until May 1995 or greater than 2.5 ng/ml after May 1995) or suspicious DRE. Men with a history of prostate cancer were excluded from study. Men completed a questionnaire, including information about hemospermia, at each screening visit. Hemospermia information from the initial questionnaire was analyzed. The relative risk of prostate cancer diagnosis in the overall prostate cancer screening population and the cohort with hemospermia was determined. Detailed prostate cancer characteristics were evaluated in those who had hemospermia and underwent radical prostatectomy. We used a multivariate logistic regression model to test the independent significance of hemospermia after adjusting for other known predictors of prostate cancer detection. Results: Prostate cancer was detected in 1,708 of the 26,126 men (6.5%) who underwent prostate cancer screening. Prostate cancer was diagnosed in 19 of the 139 men (13.7%) who reported hemospermia upon entering the prostate cancer screening study. The median age of the 139 men was 61 years (range 40 to 89). Ten of the 13 men who underwent radical retropubic prostatectomy had stage pT2 disease, while 3 had stage pT3 disease. In the logistic regression model hemospermia was a significant predictor of prostate cancer diagnosis after adjusting for age, PSA and DRE results (OR 1.73, p = 0.054). Conclusions: Hemospermia is rare (0.5%) in a prostate cancer screening population. When a man presents with hemospermia, prostate cancer screening should be vigilantly performed since hemospermia is associated with an increased risk of prostate cancer. References 1 : Evaluation of the urologic patient: history, physical examination, and urinalysis. In: . Philadelphia: W. B. Saunders Co.2002: 83. sect. I, chapt. 3. Google Scholar 2 : Hemospermia and expressed tumor in the urethra: an unusual presentation of ductal carcinoma of the prostate. J Urol2000; 163: 915. Link, Google Scholar 3 : Retrospective study of 107 patients with hematospermia. Hinyokika Kiyo1997; 43: 103. Google Scholar 4 : Prostate cancer. N Engl J Med2003; 349: 366. Google Scholar 5 : Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk. Nat Genet2002; 32: 321. Google Scholar 6 : Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet2002; 30: 181. Crossref, Medline, Google Scholar 7 : RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases. Nat Genet2002; 32: 581. Google Scholar 8 : 5-year tumor recurrence rates after anatomical radical retropubic prostatectomy for prostate cancer. J Urol1994; 152: 1837. Link, Google Scholar 9 : Prediction of prognosis for prostatic adenocarcinoma by combined histological grading and clinical staging. J Urol1974; 111: 58. Abstract, Google Scholar 10 : Hemospermia: diagnosis and management. Urology1995; 46: 463. Google Scholar 11 : Massive hemospermia: a new etiology and simplified treatment. J Urol1982; 128: 151. Link, Google Scholar 12 : The aetiology and investigation of haemospermia. Br J Urol1981; 53: 669. Google Scholar 13 : Treatment of hemospermia caused by dilated seminal vesicles by direct drug injection guided by ultrasonography. J Urol1988; 140: 991. Link, Google Scholar 14 : Endorectal coil MR imaging findings in hemospermia. Magma1999; 8: 91. Google Scholar 15 : Clinical study of hemospermia. Urology1977; 10: 562. Google Scholar 16 : Clinical significance of hematospermia. Mayo Clin Proc1974; 49: 815. Google Scholar 17 : Safety and morbidity of first and repeat transrectal ultrasound guided prostate needle biopsies: results of a prospective European prostate cancer detection study. J Urol2001; 166: 856. Link, Google Scholar From the Department of Urology, Feinberg School of Medicine, Northwestern University (MH, REB, WJC), Chicago, Illinois, and Departments of Neurology (JAVA), Psychiatry (KAR) and Surgery/Urology (WJC), Washington University, School of Medicine, St. Louis, Missouri© 2004 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKaplan S (2015) Re: Hematospermia—The Added Value of Transrectal Ultrasound to Clinical Evaluation: Is Transrectal Ultrasound Necessary for Evaluation of Hematospermia?Journal of Urology, VOL. 193, NO. 4, (1333-1333), Online publication date: 1-Apr-2015.Ahmad I and Krishna N (2018) HemospermiaJournal of Urology, VOL. 177, NO. 5, (1613-1618), Online publication date: 1-May-2007. Volume 172Issue 6 Part 1December 2004Page: 2189-2192 Advertisement Copyright & Permissions© 2004 by American Urological Association, Inc.Keywordsprostatemass screeningprostatic neoplasmsspermatozoaquestionnairesMetricsAuthor Information MISOP HAN More articles by this author ROBERT E. BRANNIGAN More articles by this author JO ANN V. ANTENOR More articles by this author KIMBERLY A. ROEHL More articles by this author WILLIAM J. CATALONA More articles by this author Expand All Advertisement PDF downloadLoading ...