Portal de Periódicos da CAPES

8/8 and 10/10 High-Resolution Match Rate for the Be The Match Unrelated Donor Registry

2014; Elsevier BV; Volume: 21; Issue: 1 Linguagem: Inglês

10.1016/j.bbmt.2014.10.002

1523-6536

Jason Dehn, Kelly Buck, Martin Maiers, Dennis L. Confer, Robert J. Hartzman, Craig Kollman, Alexander H. Schmidt, Soo Young Yang, Michelle Setterholm,

Organ Transplantation Techniques and Outcomes

Highlights•8/8 and 10/10 donor match rates vary by patient race and ethnicity.•Three-year unrelated donor registry growth resulted in 2% to 4% increase in 8/8 match rate.•Most searches did not have a matched donor identified before clarifying typing.•Most patients can find a matched donor after testing 1to 2 donors, when 1 exists.AbstractThe National Marrow Donor Program's Be The Match Registry® facilitates the worldwide utilization of unrelated donor (URD) grafts for patients in need of a hematopoietic cell transplantation. In this study, we estimate the URD match rate for patients of White (WH), Hispanic (HIS), Asian/Pacific Islander (API), and African American/Black (AFA) race and ethnic groups. We chose 1344 URD at random as "pseudo-patients" (PP) to estimate the likelihood of finding an 8/8 or 10/10 high-resolution HLA-A,-B,-C,-DRB1 (and -DQB1) matched URD. Searches were conducted in the Be The Match Registry database for each PP at 2 time points: 2009 and 2012. URD who were a potential match for a PP by low/intermediate resolution were HLA typed by sequence-based typing to resolve the matching status. The 8/8 match rate for WH PP improved from 68% in 2009 to 72% in 2012. Corresponding match rates were 41% to 44% for HIS, 44% to 46% for API, and 27% to 30% for AFA, for 2009 and 2012, respectively. The 2012 10/10 match rates were 67% for WH, 38% for HIS, 41% for API, and 23% for AFA. These results provide baseline 8/8 and 10/10 match rate estimates by race for patients seeking an URD.