Highly enantioselective reduction of prochiral ketones with N,N-diethylaniline·borane (DEANB) in oxazaborolidine-catalyzed reductions
1997; Elsevier BV; Volume: 38; Issue: 9 Linguagem: Inglês
10.1016/s0040-4039(97)00128-7
ISSN1873-3581
AutoresAshok M. Salunkhe, Elizabeth R. Burkhardt,
Tópico(s)Advanced Synthetic Organic Chemistry
ResumoA variety of prochiral ketones including phenyl, aralkyl, cycloalkyl, alkyl and tertiary alkyl are enantioselectively reduced with an oxazaborolidine catalyst (5 mol% of the Me-CBS) and N,N-diethylaniline·borane as the borane source. The enantioselectivity of the reduction produced secondary alcohols in the range of 90 to ≥99% ee.
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