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Effect of Lectins on Mouse Peritoneal Macrophage Phagocytic Activity

1994; Taylor & Francis; Volume: 23; Issue: 6-7 Linguagem: Inglês

10.3109/08820139409066837

1532-4311

Guadalupe Maldonado, Flor Porras, L M Fernandez, Lorena Vázquez, Edgar Zenteno,

Galectins and Cancer Biology

We studied the in vitro ability of lectin-treated murine peritoneal macrophages to attach and phagocytize particulate antigens. Glucose and mannose specific lectins such as Con-A and lentil lectin, as well as complex lactosamine residues specific lectins, such as Phaseolus vulgaris var. cacahuate and Phaseolus coccineus var. alubia, increased the macrophage phagocytic activity towards heterologous erythrocytes, whereas peanut agglutinin, a galactose-specific lectin, diminished the macrophage phagocytic activity. These results suggest that a galactose-N-acetyl-D galactosamine-containing structure could participate as negative modulator of the phagocytic activity.