Click Reaction: Highly Efficient Synthesis of 2,3-Dihydroquinazolin-4(1 H )-ones
2008; Taylor & Francis; Volume: 38; Issue: 21 Linguagem: Inglês
10.1080/00397910802213802
ISSN1532-2432
AutoresAhmad Shaabani, Ali Maleki, Hamid Mofakham,
Tópico(s)Synthesis and biological activity
ResumoAbstract In this work, condensation reaction of 2-aminobenzamide with various alkyl, aryl, and alicyclic aldehydes or ketones to 2,3-dihydroquinazolin-4(1H)-one derivatives in the presence of a catalytic amount of ammonium chloride in ethanol at room temperature is described. This reaction can be classified as a click chemical synthesis because of its high yields, short reaction times, and green and efficient reaction medium.
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