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An investigation of racemisation during the use of acetoacetyl-L-valine in peptide synthesis

1969; Royal Society of Chemistry; Issue: 3 Linguagem: Inglês

10.1039/j39690000350

2050-5604

Carlo Di Bello, Fernando Filira, Virgilio Giormani, Ferruccio D’Angeli,

Analytical Chemistry and Chromatography

The acetoacetyl group allows quantitative retention of configuration in the synthesis of a peptide (valylvaline methyl ester) when suitable condensing agents such as dicyclohexylcarbodi-imide alone or in the presence of N-hydroxysuccinimide are used, and hydroxylamine hydrochloride in an acidic medium is the cleavage agent.