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Streptomycin therapy in undulant fever

1947; Elsevier BV; Volume: 2; Issue: 5 Linguagem: Inglês

10.1016/0002-9343(47)90094-6

1555-7162

George Finch,

Inflammasome and immune disorders

Abstract Our series of six cases is too small to formulate any final conclusions. The experiments were interesting and the results were very encouraging. In the past, our therapy has been unsatisfactory for two reasons: (1) There were too many recurrences of the original infection, usually from two to five, and (2) extremely prolonged, exhaustive convalescent stage that followed the patient's apparent recovery from the acute phase of his illness; this period varied from four to twelve months. In the six patients treated with streptomycin the following favorable factors were noted: (1) There was an immediate decrease in the elevated temperature. (2) There was an elimination of subjective symptoms (chills, sweats, anorexia, muscle weakness) and earlier return of appetite. In the past I have always regarded the appearance of a ravenous appetite as a good omen. (3) There were no recurrences or relapses of the infection after the antibiotic was discontinued. (4) There was a marked decrease in the length of the convalescent stage. This was a very significant factor. Convalescence in the streptomycin-treated patients did not extend beyond a sixty-day period.