Automated On-Line Renewable Solid-Phase Extraction-Liquid Chromatography Exploiting Multisyringe Flow Injection-Bead Injection Lab-on-Valve Analysis
2006; American Chemical Society; Volume: 78; Issue: 8 Linguagem: Inglês
10.1021/ac052256z
ISSN1520-6882
AutoresJosé Benito Quintana, Manuel Miró, José Manuel Estela, Vı́ctor Cerdà,
Tópico(s)Pharmaceutical and Antibiotic Environmental Impacts
ResumoIn this paper, the third generation of flow injection analysis, also named the lab-on-valve (LOV) approach, is proposed for the first time as a front end to high-performance liquid chromatography (HPLC) for on-line solid-phase extraction (SPE) sample processing by exploiting the bead injection (BI) concept. The proposed microanalytical system based on discontinuous programmable flow features automated packing (and withdrawal after single use) of a small amount of sorbent ( 88%, limits of detection within the range 0.02-0.67 ng mL(-1), and coefficients of variation <11% for the column renewable mode and gives rise to a drastic reduction in operation costs ( approximately 25-fold) as compared to on-line column switching systems.
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