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Lipid-modified dendrimers as a tool for the design of nanoparticle-based multimodal MRI contrast agents

2014; SPIE; Volume: 8955; Linguagem: Inglês

10.1117/12.2036748

1996-756X

Adriano Boni, Mauro Gemmi, Claudia Innocenti, Giuseppe Bardi, Alice Bertero, Giovanni Signore, Angelo Bifone,

Gold and Silver Nanoparticles Synthesis and Applications

A fast and easy method for water transfer of iron oxide nanoparticle based on the hydrophobic interaction of oleic acid coated nanoparticles with the amphiphilic PAMAM-C12 dendrimer is described. The process may be conveniently performed in water and yields nanoparticles with good size distribution, diameter modulation and high crystallinity. The nanoparticles have been functionalized with gadolinium ions to obtain T 1 /T 2 dual mode contrast agents. Furthermore, the possibility to deliver and release lipophilic drugs was investigated.