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The epimerisation of monosaccharides by γ-irradiation in frozen, aqueous solutions

1973; Elsevier BV; Volume: 28; Issue: 1 Linguagem: Inglês

10.1016/s0008-6215(00)82859-1

1873-426X

N. K. Kochetkov, L.I. Kudrjashov, Michael Chlenov, T. Ya. Livertovskaya,

Carbohydrate Chemistry and Synthesis

This chapter presents the contribution of Nikolay Konstantinovich Kochetkov to the carbohydrate chemistry. Professor Nikolay Konstantinovich Kochetkov was a distinguished Russian scientist of the second half of the 20th century. Nikolay had researched on the preparation, reactions, and synthetic applications of β-chlorovinyl ketones and related compounds (β-aminovinyl ketones and β-ketoacetals). Efficient synthetic methods were developed and improved including C-ketovinylation and a number of useful heterocyclic compounds were synthesized. The discovery of enamine–imine tautomerism in β-amino vinyl ketones was another remarkable achievement by Nikolay at that time. Kochetkov's involvement in the carbohydrate chemistry began with the development of new methods for the synthesis of unusual monosaccharides including deoxy, amino, thio sugars, and higher monosaccharides. Sugar derivatives of α-amino acids and hydroxy amino acids were prepared as model compounds in degradative studies of glycoprotein structure. Natural nucleoside sugar diphosphates and their analogues were synthesized and assayed in enzymatic reactions to reveal their structure–function relationships.