Pyruvate and thiamine pyrophosphate potentiate cyclic nucleotide-induced steroidogenesis in isolated rat adrenocortical cells
1983; Pergamon Press; Volume: 18; Issue: 1 Linguagem: Inglês
10.1016/0022-4731(83)90321-7
ISSN1878-2353
Autores Tópico(s)Alcoholism and Thiamine Deficiency
ResumoA combination of pyruvate and thiamine pyrophosphate exhibits a strong potentiation of steroidogenesis in intact isolated rat adrenocortical cells in presence of threshold concentrations of cyclic AMP or other cyclic nucleotides. This effect is not present with ACTH as agonist and is not due to an inhibition of cyclic nucleotide phosphodiesterase. The amplification of steroidogenesis does not seem to be related to a limiting supply of reducing equivalents or steroid precursor in isolated cells. A concerted action at multiple sites is discussed.
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