Portal de Periódicos da CAPES

FOXO transcription factors: key regulators of cell fate

2006; Portland Press; Volume: 34; Issue: 5 Linguagem: Inglês

10.1042/bst0340722

1470-8752

Eric W.‐F. Lam, Richard E. Francis, Maja Petković,

Pancreatic function and diabetes

FOXO (forkhead box O) transcription factors are crucial regulators of cell fate. This function of FOXO proteins relies on their ability to control diverse and at times, opposing cellular functions, such as proliferation, differentiation, DNA repair, defence against oxidative stress damage and apoptosis, in response to hormones, growth factors and other environmental cues. This review discusses our current understanding of the regulation and role of FOXO transcription factors in determining cell fate and highlights their relevance to tumorigenesis and drug resistance.